Gastrointestinal Infections News

Children who underwent fecal microbiota transplant, or FMT, experienced a significant reduction in recurrent Clostridioides difficile infection, or CDI, and a decrease in the prevalence of antimicrobial resistance genes in their gut microbiota, according to findings published in Open Forum Infectious Diseases.

Resistance-guided direct-acting antiviral retreatment resulted in nearly 90% sustained virologic response rates among patients with hepatitis C who developed resistance-associated substitutions after failing treatment with NS5A inhibitors.

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Researchers discovered that an elevated fatty liver index was an independent risk factor for all-cause mortality in patients coinfected with hepatitis C and HIV, regardless of liver fibrosis or sustained virologic response to hepatitis therapy.

The FDA has received reports that the use of Mavyret, Zepatier or Vosevi to treat chronic hepatitis C in patients with moderate to severe liver disease has resulted in rare cases of liver injury or liver failure, according to a drug safety communication.

The U.S. Preventive Services Task Force has issued a draft recommendation that encourages clinicians to screen all adults aged 18 to 79 years for hepatitis C virus infection.

The intrigue surrounding the use of fecal microbiota transplantation to treat various gastrointestinal disorders and infections has intensified over the last several years.

Sustained virologic response after treatment for hepatitis C correlated with a reduced risk for several extrahepatic manifestations including type 2 diabetes, chronic kidney disease, and mood and anxiety disorders.

As a young medical student, I learned how tiny organisms could wreak great havoc in this world — which exposed me to the world of ID early in my medical career. I attended medical school with the goal of understanding and conquering them. During my ID rotation, I cared for a patient who had fever, vague symptoms and a rash that was biopsied. They called us, the ID service, hoping that we could offer answers. This role of a detective, collaborator, thinker and doctor is what still appeals to me the most about the practice of ID. I was in awe of the ID specialists who ascertained the etiology as secondary syphilis and treated this patient with penicillin — and I hoped someday to emulate them. Intriguing cases like this sparked my interest in this field, which only grew stronger in the years to come.

In a follow-up analysis of participants in clinical trials, researchers found that patient-reported outcome scores increased in patients who achieved sustained virologic response after treatment for hepatitis C, whereas scores decreased in those who did not.