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New York sees reduced prevalence of carbapenem-resistant K. pneumoniae infections
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Researchers reported downward trends in community- and hospital-acquired carbapenem-resistant Klebsiella pneumoniae infections in New York City.
“Carbapenem-resistant Klebsiella pneumoniae (CRKP) is one of the most commonly reported [carbapenem-resistant Enterobacteriaceae (CRE)] in health-care settings in the U.S,” Sun O. Park, MD, MS, assistant professor in the department of medicine at Albert Einstein College of Medicine, and colleagues wrote. “Knowledge of temporal trends of CRKP in NYC hospitals is critical since (1) information of temporal trends would inform decisions for antimicrobial stewardship and infection control policymaking, and (2) temporal trends of CRKP in NYC hospitals would likely predict temporal trends in various other locations.”
The researchers studied annual CRKP proportion trends in hospital-acquired infections (HAI) and community-onset infections (COI) treated in three New York City hospitals over a period of 9 years (2006-2014) and their correlation. They investigated K. pneumoniae infection data, including carbapenem susceptibility and anatomical sites; compared clinical features between CRKP and carbapenem-susceptible K. pneumoniae infections, and determined CRKP infection proportions in total K. pneumoniae infections in hospital and community settings.
Park and colleagues found that CRKP caused 17.3% of HAI K. pneumoniae compared with 7.7% of COI from 2006 to 2014. Over time, HAI and COI positively correlated (r = 0.83; P < .01) and revealed downward annual trends of CRKP proportions from 2006 to 2014 (25.8% to 10.5% in HAI; P < .001; 13.6% to 3.1% in COI; P < .001). By anatomic site, researchers observed downward trends only with urinary tract infections, or UTIs (P < .001 for both HAI and COI).
“Our findings indicate that overall CRKP proportions in HAI and COI are positively correlated in 2006-2014, while CRKP UTIs were the only anatomic sites infections that were significantly correlated,” Park and colleagues wrote. “To extend these downwards trends, judicious antibiotic use and infection control efforts should be continued in both hospital and community settings.”—by Savannah Demko
Disclosure: The researchers report no relevant financial disclosures.
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