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Intervention improved S. aureus bacteremia-related mortality
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Written protocols that emphasized quality-of-care indicators for patients with Staphylococcus aureus bacteremia increased care and decreased mortality in a group of Spanish hospitals, according to study data published online.
For this systematic review of the literature, researchers at 12 Spanish tertiary care hospitals provided hospital staff with written indicators that were associated with increased quality of care for patients with S. aureus bacteremia, which specifically related to blood cultures, medication use and early source control.
The researchers reported that the intervention was linked to boosted compliance with follow-up blood cultures, source control, adjustment of vancomycin dose according to trough levels and appropriate antimicrobial use duration.
Also, it was independently associated with a decrease in 14-day and 30-day mortality, they said.
The researchers noted some study limitations, specifically that “it has the inherent limitations of quasi-experimental, before-after designs. Although our methodology tried to control for potential confounding factors by using multivariate analysis, it is possible that other unmeasured factors influenced the results.”
Disclosure: Study researcher Jesús Rodríguez-Baño, MD, PhD, has served as a consultant and speaker for Astellas, Merck, Novartis, Pfizer and Roche.
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