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HPV increased risk for laryngeal cancer
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HPV infection was associated with a higher risk for laryngeal squamous cell carcinoma, researchers from China have found. The HPV-16 subtype was especially associated with the increased risk.
“The association between HPV infection and laryngeal cancer risk was not substantially influenced by factors that might influence HPV prevalence, such as geographic region, clinical stage and location of the cancer and HPV DNA detection methods,” the researchers wrote in the Journal of Infectious Diseases. “Further studies are needed to verify the relationship between HPV infection and laryngeal cancer and to explore the underlying mechanisms of their association.”
The researchers conducted a systematic review and meta-analysis of 55 studies on HPV infection and laryngeal cancer that were published from 1990 to May 15, 2012. The studies, which included 2,559 cases of laryngeal cancer, were identified from a search on the PubMed, Medline and Embase databases.
Overall, the prevalence of HPV in laryngeal cancer was 28% (95% CI, 23.5-32.9). There were 20 reported genotypes among the patients, but the most common was HPV-16, which had a prevalence of 19.8% (95% CI, 15.7-24.6). There was a significant association between HPV and laryngeal cancer risk, with an OR of 5.39 (95% CI, 3.25-8.94). The OR for HPV-16 and laryngeal cancer risk was 6.07 (95% CI, 3.44-10.7). The OR was higher than that for breast cancer, oropharyngeal cancer and oral cancer.
Disclosure: The researchers report no relevant financial disclosures.
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