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Specific comorbidities up risk for IPD in adults with HIV
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SAN FRANCISCO — Researchers from Paris suggest that having uncontrolled HIV, being of African descent and having low CD4 cell counts are significant risk factors for invasive pneumococcal disease in adults with HIV, according to data presented at the 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy.
For the study, researchers pooled data on cases of invasive pneumococcal disease (IPD) in patients being treated at a reference center for the management of HIV in Paris between 2000 and 2011. The cohort included 42 adults with HIV and IPD. The researchers matched two controls with HIV but not IPD per adult with HIV and IPD. The mean age of the patients was 42 years; 80% were male; and 43% were black.
At the time of IPD diagnosis, 64% of adults had at least one comorbidity; CD4 cell counts were <200/mm3 in 50%; and plasma HIV/RNA levels were <400 copies/mL in 24%.
Results from multivariate analysis indicated that when compared with controls, patients with HIV and IPD were more likely to have CD4 cell counts <200/mm3 (OR=6.93; P,.05), uncontrolled HIV (OR=5.56; P,.01) and to be of African origin (OR=4.26; P,.05).
“Comorbidities stand out as a major risk factor, as in the general population,” the researchers wrote in the abstract. “Control of HIV infection, as well as the management of comorbidities, should be the cornerstones of IPD prevention in this population.”
For more information:
Munier A. #019. Presented at: 52nd ICAAC; Sept. 9-12, 2012; San Francisco.
Disclosure: The researchers report no relevant financial disclosures.