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Total fat, lean mass predicted hip and neck BMD in women with HIV
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Recent data suggest that total fat and lean mass were strong predictors of total hip and femoral neck bone mineral density in women with HIV.
Researchers conducted a study of 440 women, of whom 318 had HIV. All women completed up to three dual X-ray absorptiometry scans. Women with HIV were older, more likely to have hepatitis C infection and be postmenopausal. Women with HIV also had lower BMI and lower trunk, leg and total body fat than women without HIV.
Increased fat-free mass was independently associated with increased bone mineral density (BMD) in the lumbar spine, total hip and femoral neck. Increased total body fat also was associated with increased BMD in the total hip and femoral neck. Researchers also found that greater trunk fat, but not greater leg fat, was associated with increased BMD in the total hip and femoral neck.
“Clarification of the mechanisms underlying these associations may have important implications for bone density screening and preventive interventions for reduced BMD in HIV-infected women, particularly those with alterations in body composition,” the researchers wrote.
Disclosure: The researchers report no relevant financial disclosures.
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