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Multiple factors influenced BMD in women on PrEP

Issue: June 2012

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There are several factors that affect bone mineral density in women, and more bone health data from healthy African women are needed before the implementation of pre-exposure prophylaxis, according to researchers.

Nyaradzo Mgodi, MD, of the University of Zimbabwe, and colleagues conducted a substudy of women in Uganda and Zimbabwe included in the Vaginal and Oral Interventions to Control the Epidemic (VOICE) trial, which compared tenofovir (Viread, Gilead) and combination tenofovir and emtricitabine (Truvada, Gilead) as pre-exposure prophylaxis (PrEP). The substudy evaluated bone mineral density (BMD) in these women.

At study enrollment, BMD of lumbar spine and total hip were assessed among 517 women. Mean BMD was 0.97 g/cm² for lumbar spine and 0.96 g/cm² for total hip. The researchers evaluated independent factors associated with BMD.

Data from a univariate analyses indicated a lower total hip BMD was associated with younger age, lower BMI and lower physical activity. Decreased lumbar spine BMD was associated with lower BMI, lower physical activity, shorter duration of implant use and longer duration of injectable contraception use.

In a multivariate analysis, lower lumbar spine and total hip BMD were associated with living in Uganda, any history of injectable contraception use, lower BMI and lower physical activity level.

“There’s been limited information about bone health in African women,” Mgodi said in a press release. “That’s why we felt it was important to do this study. We have to have a starting place before we can understand the potential effects of these drugs as HIV prevention. The data will be critical for consideration of PrEP implementation.”

References:

• Mgodi N. Factors associated with bone mineral density in healthy African women enrolling in a PrEP study. Presented at: International Microbicides Conference; April 15-18, 2012; Sydney, Australia.

Disclosures:

• The researchers report no relevant financial disclosures.