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HIV upped risk for malaria, Plasmodium parasitemia in adults
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PHILADELPHIA — Adults with HIV-1 infection were more likely to have Plasmodium parasitemia and combined parasitemia or history of clinical malaria, according to findings from the Kericho cohort study.
Douglas Shaffer, MD, MHS, of the US Military HIV Research Program and Walter Reed Army Institute of Research in Kericho, Kenya, and colleagues evaluated the association between HIV, Plasmodium parasitemia and clinical malaria in adults participating in the 36-month prospective study in Kenya.
Shaffer and colleagues estimated the OR for prevalence of cases at baseline and the HR for follow-up incident cases between HIV and two malaria outcomes (Plasmodium parasitemia and combined parasitemia and/or history of clinical malaria).
Of 2,801 participants enrolled in the study, the researchers identified 14.3% with HIV at baseline and 33.2% with HIV plus parasitemia and/or clinical malaria prevalence.
Compared with non–HIV-infected participants, more HIV-infected participants had baseline parasitemia (6% vs. 3.5%, P=.02) and parasitemia/clinical malaria (40% vs. 31%, P,.01) with ORs of 1.73 (95% CI, 1.04-2.80) and 1.53 (95% CI, 1.22-1.91), respectively.
Overall, the researchers reported that adults with baseline HIV were at increased risk for both incident parasitemia (HR=1.69; 95% CI, 1.29-2.21) and parasitemia/clinical malaria (HR=1.41; 95% CI, 1.19-1.69).
For more information:
- Shaffer D. #22. Presented at: the American Society of Tropical Medicine and Hygiene 60th Annual Meeting; Dec. 4-8, 2011; Philadelphia.
Disclosure: The researchers report no relevant financial disclosures.
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