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CC genotype associated with sustained virologic response to HCV

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A single nucleotide polymorphism upstream from IL28B predicted treatment response in patients with hepatitis C, according to results from a study conducted in Italy. To correlate viral genotype with response to antiviral therapy, researchers analyzed the IL28B SNP rs12979860 frequencies in 46 patients with HCV-1 and 44 with HCV-2, along with 50 participants as a control. They also conducted a correlation analysis between the gene expression of SOCS3 and IL28B in both groups.

The results were presented in a poster at the 2011 Meeting of the American Association for the Study of Liver Diseases in San Francisco.

Researchers found that IL28B SNP rs12979860 frequencies found in the control group were similar to those found in patients with HCV for both the C allele (69% vs. 64.6%) and the T allele (31% vs. 35.4%). There was a confirmed association between CC genotype in patients with HCV and sustained virologic response (CC=50.9%, CT=41.5%, TT=7.5%).

Gene expression analysis performed on 89 patients with HCV and 45 healthy participants showed that viral infection induced IL28B, but induction appeared to be mediated in HCV-2 in a greater extent than HCV-1. The analysis evidenced the opposite trend for SOCS3 expression between the two groups of patients.

A correlation analysis performed on healthy participants showed a direct correlation between expression of SOCS3 and IL28B. Researchers found an inverse correlation in patients with HCV. Researchers said inverse correlation “opens a new scenario on the combined use of both genetic variants to predict the response after antiviral therapy.”

For more information:

• Russo R. #389. Presented at: 2011 Meeting of the American Association for the Study of Liver Diseases; Nov. 4-8, 2011; San Francisco.

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