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Slight decrease observed in HIV-associated neurocognitive disorders

Issue: August 2011

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Researchers observed a slight decrease in the prevalence of neurocognitive disorders associated with HIV infection between 1996 and 2010. Age, level of education and current CD4 cell count were significantly associated with HIV-associated neurococognitive disorders, according to a presenter at the 6th IAS Conference on HIV Pathogenesis, Treatment and Prevention in Rome.

Pietro Balestra, PsyD, in the clinical department at the National Institute of Infectious Diseases in Rome, and colleagues conducted a 15-year survey and assessed the prevalence of and risk factors for HIV- associated neurocognitive disorders among 1,375 patients on antiretroviral therapy with no confounding conditions.

Data indicated that calendar year was associated with a slight decrease in the prevalence for HIV-associated neurocognitive disorders (OR=0.97; P=.016).

Those with HIV-associated neurocognitive disorders were more likely to be older (44.8 years vs. 40.9 years; P<.0001); aged older at first HIV testing (36.8 years vs. 34.5 years; P<.0001); received lower education (10.1 years vs. 12.6 years; P<.0001); were exposed to HIV for longer (8.3 years vs. 6.8 years; P<.0001); were more likely to be coinfected with HCV (54.7% years vs. 45.3% years; P<.0001) and to be stage C as according to the CDC (58.9% years vs. 40.1% years; P<.001).

Both current (351 cells/cmm vs. 483 cells/cmm; P<.0001) and nadir (156 cells/cmm vs. 229 cells/cmm; P<.0001) mean CD4 cells were lower.

“Multivariate analysis indicated current CD4 count (OR=0.89; 95%CI, 0.89-0.96), age (OR=1.04; 95%CI,1.02-1.06), and years of education (OR=0.88; 95%CI, 0.84-0.92) remained significantly associated with HIV-associated neurocognitive disorders,” the researchers wrote in the study abstract.

For more information:

• Balestra P. #MOAB0103. Presented at: The 6th IAS Conference on HIV Pathogenesis, Treatment and Prevention; Rome; July 17-20, 2011.

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