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Transplantation News
VIDEO: Post-transplant recovery protocol shortens pediatric ICU stays, improves experience
In this Healio video, Andrew J. Costandi, MD, MMM, details the Enhanced Recovery After Liver Transplantation protocol at Children’s Hospital Los Angeles, which shortened post-transplant ICU stays from 7 to 3 days in pediatric patients.
Non-liver-related mortality can be higher in NAFLD ‘depending on age, fibrosis stage’
A patient outcomes simulator found that non-liver-related mortality could surpass liver-related mortality in patients with nonalcoholic fatty liver disease, depending on age and fibrosis stage at diagnosis, noted data in JAMA Network Open.
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Liver transplantation ‘remains the standard of care’ for HCC patients, regardless of age
Despite increased perioperative risks in older patients with hepatocellular carcinoma and cirrhosis, orthotropic liver transplantation provides greater survival benefit compared with ablative therapies, according to new research.
Liver transplant recipients gain up to 17 life-years from living donors vs. donor waitlist
A case-control study in JAMA Surgery revealed that patients with end-stage liver disease had a 34% reduction in mortality after living-donor liver transplantation compared with patients who remained on a wait list for a deceased donor.
Downstaging HCC to Milan criteria prior to liver transplant yield ‘excellent outcomes’
Researchers reported excellent 10-year outcomes among patients with hepatocellular carcinoma that was downstaged to within Milan criteria prior to liver transplant, according to a multicenter analysis published in JAMA Surgery.
Expert: Virus pairing creates ‘perfect storm’ for unexplained hepatitis surge in children
New research has linked the incidence of unexplained hepatitis in pediatric patients to a pair of viruses — adenovirus type F41 and adeno-associated virus 2 — as well as potential markers of genetic mutation.
Children younger than 12 years now exempt from pretransplant HIV, HBV, HCV testing
The U.S. Public Health Service has published an updated recommendation for solid organ transplant candidates aged younger than 12 years, which now exempts them from testing for HIV and hepatitis B and C viruses during surgical admission.
Older age, MELD score predict survival among patients declined for early LT
LONDON — Lower MELD score predicted short- and long-term survival in patients with severe alcohol-associated hepatitis who were declined for early liver transplantation, according to research presented at the International Liver Congress.
Liver transplantation linked to lower antibody, T-cell response to COVID-19 vaccine
LONDON — Patients who received a liver transplant had significantly reduced antibody and T-cell responses to SARS-CoV-2 vaccination compared with healthy controls, according to research presented at the International Liver Congress.
Alcohol use disorders may drive HCC progression in patients with diabetes
LONDON — Alcohol misuse was a primary trigger for progression of liver disease to hepatocellular carcinoma among a subset of French patients with type 2 diabetes, according to data presented at the International Liver Congress.
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