Liver Injury/Regeneration News

BOSTON — Liver fibrosis negatively influenced cognitive performance in women, independently of whether or not they had hepatitis C virus infection and HIV, according to research presented at CROI 2016.

In a retrospective study, researchers found that patients who received total IV anesthesia with propofol experienced less pain post-liver surgery vs. patients who received sevoflurane.

In a phase 2 study, elafibranor was well-tolerated and led to resolved nonalcoholic steatohepatitis without worsening fibrosis, according to published findings.  

The Medicines & Healthcare products Regulatory Agency in the U.K. is recalling 91,800 packs of St John’s Wort tablets as a precaution because of product contamination that may lead to potential liver damage, according to a medical alert.

In a prospective study, researchers found elastography to be effective for diagnosing liver fibrosis and cirrhosis among patients at risk for liver fibrosis due to alcohol consumption.

In a cross-sectional analysis, researchers found aspirin use was associated with decreased indices for liver fibrosis, suggesting aspirin can reduce further liver injury and chronic liver disease, according to published findings.

In a prospective study, researchers found high-volume plasma exchange increased the odds of survival without liver transplantation among patients with acute liver failure, according to published findings.

A small number of Indian patients developed Stevens-Johnson syndrome or toxic epidermal necrosis from the same medication that resulted in drug-induced liver injury and showed poor long-term outcomes.  

Treating patients with cirrhosis with nonselective beta blockers was safe and improved 28-day survival if diagnosed with acute-on-chronic liver failure, according to study data.

Researchers found that the alternative splicing of specific genes, including epithelial splicing regulatory protein 2, supports postnatal liver maturation and continues over time.