Liver Injury/Regeneration News

Early alcohol rehabilitation reduced 30-day readmission, alcohol relapse and mortality among patients hospitalized for alcohol-related hepatitis, according to data published in Clinical Gastroenterology and Hepatology.

VIENNA — Fecal microbiota transplant, delivered via capsule, lessened hospitalizations for patients with hepatic encephalopathy while improving cognitive function, according to data presented during the International Liver Congress 2019.

VIENNA — GKT831 achieved rapid dose- and time-dependent reductions in markers of cholestatic bile duct disease and liver injury in patients with primary biliary cholangitis who had an inadequate response to ursodeoxycholic acid, according to a presentation at International Liver Conference 2019.

Many chronic liver complications such as autoimmune hepatitis and nonalcoholic fatty liver disease do not have approved therapies for direct treatment, but the current hepatology pipeline includes several candidates that have recently demonstrated safety in early trials and some that met top-line phase 3 results.

Drug-induced liver injury can occur following the use of several different drugs, both prescription and over-the-counter, and is more common among adults than children. Additionally, the signs and duration of drug-induced liver injury vary widely.

More than half of patients who presented in hospital with acetaminophen-induced acute liver injury or acute liver failure had undetectable levels of acetaminophen, according to a study recently published in Clinical Gastroenterology and Liver Disease.

Barriers to initiating a Mediterranean diet — shown to improve liver health in patients with nonalcoholic fatty liver disease — included an obesogenic environment, life stressors, and demand for convenience, according to a study published in Clinical Gastroenterology and Liver Disease.

Exemplar Genetics in partnership with Mayo Clinic launched a new company, Cytotheryx, focused on the development of a high-quality source of human liver cells or hepatocytes for clinical research, according to a press release.

This year at the American College of Gastroenterology Annual Meeting, several hepatology specialists discussed the changing landscape of liver disease health care, such as increasing rates of nonalcoholic fatty liver disease which is quickly becoming the number one indication for liver transplantation.

PHILADELPHIA – Use of nonsteroidal anti-inflammatory drugs and aspirin — but not acetaminophen — correlated with an increased risk for microscopic colitis, according to a presentation at the American College of Gastroenterology Annual Meeting.