Drug Metabolism/Pharmacology News

SAN FRANCISCO — Combination therapy with Kineret, Trental and zinc sulfate showed only a slight trend toward 90-day improved survival in patients with alcoholic hepatitis but otherwise showed little benefit, according to data presented at The Liver Meeting 2018.

BioIVT announced results of their research into cholestatic drug-induced liver injury and the BSEP bile acid transporter, according to a press release.

Patients aged 75 to 85 years with more than eight diagnosed diseases or conditions were at the highest risk for polypharmacy, according to findings recently published in BMC Family Practice.

Researchers were able to establish an etiologic diagnosis among nearly 50% of patients with previously indeterminate etiology of acute liver failure using a systematic analysis strategy that included diagnostic algorithms and expert opinion.

PARIS — Beginning Wednesday, April 11, Healio Gastroenterology and Liver Disease will provide live coverage from the International Liver Congress 2018.

A study of more than 1,000 medications spanning all therapeutic classes showed that one in four non-antibiotic drugs inhibited the growth of at least one species of bacteria in the gut microbiome.

Anabolic steroids were the most common cause of drug-induced liver injury among patients with heavy alcohol consumption, according to a recently published study. However, heavy alcohol consumption did not correlate with worse outcomes compared with nondrinkers.

Acetaminophen-induced acute liver injury and failure are more common in women than men, according to recently published data. Women also have greater critical care needs and have an increased risk for severe hepatic encephalopathy, potentially related to increased use of sedatives.

ORLANDO — In this exclusive video from Advances in IBD 2017, Adam S. Cheifetz, MD, FACG, from the Beth Israel Deaconess Medical Center, discusses complementary and alternative medication use in inflammatory bowel disease.

Alanine aminostransferase maintained better levels at mid-childhood when children took in a higher amount of the alpha-tocopherol isoform of vitamin E at early childhood, according to data published in Hepatology.