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Cirrhosis/Liver Failure News
‘Age should not be a contraindication’ for liver transplant in older patients with ACLF
Older adult patients with acute-on-chronic liver failure had significantly higher waitlist mortality but “acceptable” 1-year survival after liver transplantation, according to data in Clinical Gastroenterology and Hepatology.
Less than 25% of patients with cirrhosis, low bone density are treated for osteoporosis
Patients with cirrhosis are less frequently screened for osteoporosis compared with the general population, and less than 25% with low bone density actually receive treatment, according to research in Alimentary Pharmacology & Therapeutics.
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VIDEO: Unmet need in ACLF presents ‘very large opportunity’ for new technology
In this Healio video exclusive, Dean Hum, PhD, chief scientific officer at Genfit, outlines five ongoing programs in the company’s acute-on-chronic liver failure development pipeline, which recently were presented at The Liver Meeting.
ACG publishes new guideline for management of alcohol-associated liver disease
A new clinical guideline published in the American Journal of Gastroenterology underscored the need to overcome barriers to alcohol use disorder treatment and expand multidisciplinary care for patients with alcohol-associated liver disease.
FDA grants orphan drug designation to Ocelot Bio’s therapeutic peptide for ascites
The FDA has granted orphan drug designation to Ocelot Bio’s OCE-205, a mixed vasopression 1a receptor agonist-antagonist peptide for the treatment of ascites resulting from all causes except cancer, according to a company release.
Binge drinking, genetic predisposition linked to sixfold higher risk for cirrhosis
Heavy binge drinking and high polygenic risk score were associated with a sixfold higher relative excess risk for alcohol-related cirrhosis, with the presence of diabetes mellitus further increasing the risk, researchers reported.
Oral androgen receptor agonist improves sarcopenia, encephalopathy in cirrhosis
BOSTON — LPCN 1148, an oral androgen receptor agonist, improved sarcopenia, hepatic encephalopathy and other biomarkers associated with end-stage liver disease among men with advanced cirrhosis and clinical decompensation.
Pegozafermin improves stage 4 fibrosis, noninvasive markers in MASH patients
BOSTON — Pegozafermin improved fibrosis and other key noninvasive tests at 24 weeks in patients with metabolic dysfunction-associated steatohepatitis-related cirrhosis, according to data presented at The Liver Meeting.
Risk for cirrhosis 50% higher in young women after first episode of alcoholic hepatitis
BOSTON — Female adolescents and young adults have higher rates of liver-related mortality and a 50% higher risk for cirrhosis and decompensation after surviving their first presentation of alcoholic hepatitis, according to data.
ENLIVEN extension topline data: Pegozafermin sustains ‘robust benefits’ in NASH at week 48
Topline findings from an extension of the phase 2b ENLIVEN trial showed that pegozafermin sustained improvements in fibrosis and disease resolution for patients with nonalcoholic steatohepatitis at 48 weeks, 89bio announced.
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