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November 18, 2024
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CDC: 1 dead in multistate outbreak of E. coli linked to organic carrots

Cirrhosis/Liver Failure News

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January 11, 2024
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‘Age should not be a contraindication’ for liver transplant in older patients with ACLF

‘Age should not be a contraindication’ for liver transplant in older patients with ACLF

Older adult patients with acute-on-chronic liver failure had significantly higher waitlist mortality but “acceptable” 1-year survival after liver transplantation, according to data in Clinical Gastroenterology and Hepatology.

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January 10, 2024
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Less than 25% of patients with cirrhosis, low bone density are treated for osteoporosis

Less than 25% of patients with cirrhosis, low bone density are treated for osteoporosis

Patients with cirrhosis are less frequently screened for osteoporosis compared with the general population, and less than 25% with low bone density actually receive treatment, according to research in Alimentary Pharmacology & Therapeutics.

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AdobeStock_Carrots_1200x630
November 18, 2024
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CDC: 1 dead in multistate outbreak of E. coli linked to organic carrots

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January 08, 2024
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VIDEO: Unmet need in ACLF presents ‘very large opportunity’ for new technology

VIDEO: Unmet need in ACLF presents ‘very large opportunity’ for new technology

In this Healio video exclusive, Dean Hum, PhD, chief scientific officer at Genfit, outlines five ongoing programs in the company’s acute-on-chronic liver failure development pipeline, which recently were presented at The Liver Meeting.

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January 04, 2024
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ACG publishes new guideline for management of alcohol-associated liver disease

ACG publishes new guideline for management of alcohol-associated liver disease

A new clinical guideline published in the American Journal of Gastroenterology underscored the need to overcome barriers to alcohol use disorder treatment and expand multidisciplinary care for patients with alcohol-associated liver disease.

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December 20, 2023
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FDA grants orphan drug designation to Ocelot Bio’s therapeutic peptide for ascites

FDA grants orphan drug designation to Ocelot Bio’s therapeutic peptide for ascites

The FDA has granted orphan drug designation to Ocelot Bio’s OCE-205, a mixed vasopression 1a receptor agonist-antagonist peptide for the treatment of ascites resulting from all causes except cancer, according to a company release.

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December 14, 2023
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Binge drinking, genetic predisposition linked to sixfold higher risk for cirrhosis

Binge drinking, genetic predisposition linked to sixfold higher risk for cirrhosis

Heavy binge drinking and high polygenic risk score were associated with a sixfold higher relative excess risk for alcohol-related cirrhosis, with the presence of diabetes mellitus further increasing the risk, researchers reported.

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December 02, 2023
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Oral androgen receptor agonist improves sarcopenia, encephalopathy in cirrhosis

Oral androgen receptor agonist improves sarcopenia, encephalopathy in cirrhosis

BOSTON — LPCN 1148, an oral androgen receptor agonist, improved sarcopenia, hepatic encephalopathy and other biomarkers associated with end-stage liver disease among men with advanced cirrhosis and clinical decompensation.

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November 30, 2023
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Pegozafermin improves stage 4 fibrosis, noninvasive markers in MASH patients

Pegozafermin improves stage 4 fibrosis, noninvasive markers in MASH patients

BOSTON — Pegozafermin improved fibrosis and other key noninvasive tests at 24 weeks in patients with metabolic dysfunction-associated steatohepatitis-related cirrhosis, according to data presented at The Liver Meeting.

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November 28, 2023
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Risk for cirrhosis 50% higher in young women after first episode of alcoholic hepatitis

Risk for cirrhosis 50% higher in young women after first episode of alcoholic hepatitis

BOSTON — Female adolescents and young adults have higher rates of liver-related mortality and a 50% higher risk for cirrhosis and decompensation after surviving their first presentation of alcoholic hepatitis, according to data.

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November 27, 2023
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ENLIVEN extension topline data: Pegozafermin sustains ‘robust benefits’ in NASH at week 48

ENLIVEN extension topline data: Pegozafermin sustains ‘robust benefits’ in NASH at week 48

Topline findings from an extension of the phase 2b ENLIVEN trial showed that pegozafermin sustained improvements in fibrosis and disease resolution for patients with nonalcoholic steatohepatitis at 48 weeks, 89bio announced.

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