Cirrhosis/Liver Failure News

HistoIndex announced a collaboration with CymaBay to evaluate the efficacy of seladelpar for nonalcoholic steatohepatitis in a randomized control phase 2b study using HistoIndex’s Genesis 200 multiphoton digital pathology system, according to a press release.

New data showed that in nonalcoholic fatty liver disease, patients with cirrhosis were more likely to experience liver-related events while those with bridging fibrosis were more likely to experience non-hepatic cancers and vascular events.

A hemostatic powder applied during an upper endoscopy as an early intervention was effective for treating acute variceal bleeding in patients with liver cirrhosis, according to research published in Gut.

Cirrhotic liver damage is a significant concern in hepatology as treatment is limited to a focus on the underlying cause. However, recent studies have highlighted how to improve fibrosis screening and risk factors that may act as a warning sign for progression to cirrhosis.

Corticosteroid therapy reduced mortality risk within 28 days of treatment among patients with severe alcoholic hepatitis compared with pentoxifylline or placebo, although the effect did not remain in the following 6 months, according to a recently published meta-analysis.

Deep learning radiomics of elastography demonstrated superior predictive value in assessing cirrhosis and advanced fibrosis compared with 2D shear wave elastography and biomarkers among patients with chronic hepatitis B, according to recently published data.

Compliance with hepatocellular carcinoma surveillance correlated with early diagnosis, better allocation of curative treatment and longer overall survival among patients with hepatitis C- or hepatitis B-associated compensated cirrhosis, according to a recently published study.

Patients with acute-on-chronic liver failure admitted to the ICU had clinical outcomes comparable to patients in the ICU without chronic liver disease and similar baseline severity of illness characteristics, according to a recently published study.

Researchers using liver stiffness measurement found significant and comparable prevalence of advanced fibrosis between patients with chronic hepatitis C recruited from primary care practices and those recruited from a hospital cohort, according to a recently published study.

A lower subcutaneous adipose tissue index correlated with higher mortality in women with cirrhosis, while lower skeletal muscle predicted mortality in men with cirrhosis, according to a recently published study.