Cirrhosis/Liver Failure News

Liver disease-related mortality rates varied significantly by geographic region in the Untied States with some of the highest rates in the South and the West, in areas with higher Hispanic populations, and areas of lower household income, according to a recently published study.

Recent studies of early liver fibrosis and advanced fibrosis or cirrhosis have analyzed several noninvasive methods to accurately detect fibrosis, stage fibrosis, and improve survival through early detection. Other studies have taken the next step after detection to determine the safety of certain gastrointestinal procedures in patients with fibrosis and hospitalization outcomes.

Patients with hepatitis C genotype 3 with compensated cirrhosis achieved a sustained virologic response rate higher than 90% after treatment with Epclusa with or without ribavirin, according to results of a recently published phase 3 study.

Elastography point quantification displayed good to excellent performance as a noninvasive measurement of liver fibrosis staging among patients with chronic liver disease, according to a recently published study.

This year at the Digestive Disease Meeting, physicians noted a significant increase in studies focused on the growing obesity epidemic and the gut microbiome as related to gastrointestinal complications. Additionally, the meeting included several presentations on nonalcoholic fatty liver disease treatment, outcomes in hepatitis C and hepatitis B, early detection of liver cancer, and reviews on recent obesity and gut microbiome studies.

WASHINGTON — In this exclusive video perspective from Digestive Disease Week 2018, Steven L. Flamm, MD, chief of the Liver Program at Northwestern University Feinberg School of Medicine in Illinois, reviews some of the important clinical presentations in liver disease from the meeting.

WASHINGTON, D.C. — Patients with nonalcoholic fatty liver disease and compensated cirrhosis who underwent bariatric surgery did not have higher rates of in-hospital mortality compared with patients without cirrhosis who underwent the procedure, according to a study presented at Digestive Disease Week 2018.

Incorporation of age-based diagnostic recommendations into electronic medical records for children with acute liver failure reduced indeterminant diagnoses and may improve outcomes by reducing liver transplantation rates without an increase in mortality, according to a recently published study.

Neutrophil-to-lymphocyte ratio as a biomarker correlated with 1-year mortality after nonelective hospitalization in patients with cirrhosis, according to published results of a retrospective study.

Results of two phase 3 trials showed that Doptelet significantly reduced the need for platelet transfusions or rescue procedures for bleeding compared with placebo in patients with thrombocytopenia and chronic liver disease who underwent a scheduled procedure.