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Autoimmune/Cholestatic/Biliary Diseases News
ASSERT: Bylvay outperforms placebo in reducing pruritis, bile acids in Alagille syndrome
Treatment with Bylvay resulted in a “significantly greater” change from baseline to week 24 in mean scratching scores and serum bile acids vs. placebo among pediatric patients with Alagille syndrome, according to ASSERT study results.
Patient dosing continues in clinical trial of novel gene therapy for Wilson’s disease
A European clinical stage biotech company announced dosing of the first patient in cohort 2 of its ongoing phase 1/2 GATEWAY clinical trial of lead candidate VTX-801 to treat Wilson’s disease.
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Seladelpar normalizes ALP, reduces pruritis vs. placebo in primary biliary cholangitis
A “significantly greater” percentage of patients with primary biliary cholangitis achieved biochemical response, alkaline phosphatase normalization and reduction in pruritis when treated with seladelpar vs. placebo, according to a study.
FDA approves Livmarli for pruritus in progressive familial intrahepatic cholestasis
The FDA has approved Mirum Pharmaceuticals’ Livmarli oral solution for treatment of cholestatic pruritus in patients aged 5 years and older with progressive familial intrahepatic cholestasis, according to a company release.
Semaglutide can reduce severity of liver disease in people with HIV, study shows
DENVER — A low weekly dose of semaglutide can safely minimize what used to be called nonalcoholic fatty liver disease in people with HIV, a first-of-its-kind study found.
‘Show your stripes:’ Rare Disease Day allows patients to share their stories, spread awareness
More than 300 million people worldwide, including one in every 10 Americans, are living with a rare disease, yet these individuals and their families are often left isolated and without answers.
Maternal intestinal, genitourinary infections raise risk for biliary atresia in offspring
Offspring born to mothers with prenatal or third trimester intestinal infection or genitourinary tract infection experienced a significantly higher risk for biliary atresia, according to a study in JAMA Network Open.
VIDEO: Interim INTEGRIS-PSC trial results ‘promising’ in primary sclerosing cholangitis
BOSTON — Healio spoke with James L. Boyer, MD, FACEP, about interim results from the phase 2a INTEGRIS-PSC trial presented at The Liver Meeting, which showed bexotegrast reduced biomarkers of liver fibrosis vs. placebo.
VIDEO: Preclinical research investigates role of Claudin-1 in cholangiocarcinoma
BOSTON — Healio spoke with James L. Boyer, MD, FACEP, about research assessing the role of Claudin-1 in cholangiocarcinoma, which was presented at The Liver Meeting.
Patients with MASLD lost less weight after bariatric surgery, study finds
BOSTON — Patients with metabolic dysfunction-associated steatotic liver disease who underwent bariatric surgery lost less weight over 5 years than those without MASLD, according to research presented at The Liver Meeting.
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Headline News
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Headline News
Burnout, withdrawal remain ‘alarmingly high’ among physicians and residents
September 17, 20242 min read -
Headline News
Over one-third of adults not planning on receiving recommended vaccines this fall
September 18, 20242 min read -
Headline News
Popular home BP devices unable to provide accurate readings for millions due to sizing
September 19, 20242 min read