Neuro-Oncology News

Pencil beam scanning proton therapy consistently delivered the lowest amount of radiation to the hippocampus and temporal lobes of pediatric patients with brain tumors compared with two other types of radiotherapy, according to study results presented at European Society for Radiotherapy and Oncology Congress.

Administering radiation therapy immediately after surgery to children aged younger than 3 years with ependymoma extended EFS to levels seen in older children, according to results of a phase 2 trial published Journal of Clinical Oncology.

An international randomized phase 3 trial is underway to evaluate the efficacy of intraoperative radiotherapy for patients with glioblastoma multiforme.

Ivy Brain Tumor Center at The Barrow Neurological Institute has launched a program that offers phase 0 trials to accelerate the drug approval process for patients with glioblastoma.

Administering pembrolizumab to patients with glioblastoma before surgery appeared to significantly improve OS compared with administration after surgery, according to results of a randomized, multi-institution trial published in Nature Medicine.

Cancer screening in presymptomatic patients with Li-Fraumeni syndrome appeared cost-effective for third-party payers, according to results of a study published in Pediatric Blood and Cancer.

ATLANTA — A research team at St. Jude Children’s Research Hospital has identified a single nucleotide polymorphism that may increase risk for stroke among childhood cancer survivors treated with cranial radiation therapy, according to a report from the St. Jude Cohort Lifetime study presented at the American Association for Cancer Research Annual Meeting.

ATLANTA — An autologous cell vaccine composed of glioblastoma tumor cells and an antisense molecule against insulin-like growth factor type 1 receptor DNA/mRNA prolonged PFS and OS among adults with newly diagnosed glioblastoma compared with historical data of patients treated with standard of care, according to phase 1b study results presented at American Association for Cancer Research Annual Meeting.

Researchers at Washington University School of Medicine in St. Louis have identified distinct molecular signatures of glioblastoma that may explain differences in treatment responses and survival between men and women.

The Right to Try Act has raised concerns about late referrals to palliative care, particularly for children with cancer, according to a commentary published in JAMA Oncology.