Hematology News

The association between cancer and thrombosis has been known for more than a century.

Patients with acquired thrombotic thrombocytopenic purpura experienced a faster normalization of platelet count when treated with caplacizumab than placebo, according to results of a randomized phase 3 trial published in The New England Journal of Medicine.

An inverse relationship may exist between BMI and palbociclib-induced neutropenia, according to study results presented at Miami Breast Cancer Conference.

Advancing age and injury severity appeared to be the only individual risk factors consistently associated with venous thromboembolism among individuals immobilized following a lower limb injury, according to results of a systematic review of several studies published in Journal of Thrombosis and Haemostasis.

An ex vivo-expanded umbilical cord blood unit appeared safe and effective as a standalone hematopoietic stem cell graft, shortening time to neutrophil and platelet recovery, according to results of a phase 2 study published in Journal of Clinical Oncology.

Hematological immune-related adverse events associated with PD-1 or PD-L1 inhibitors, such as neutropenia and hemolytic anemia, are rare but potentially fatal and warrant earlier detection and better management, according to a descriptive observational study published in The Lancet Hematology.

Direct oral anticoagulants did not appear associated with a higher incidence of intracranial hemorrhage compared with low-molecular-weight heparin in patients with brain metastases or primary brain tumors, according to results of a retrospective study published in Journal of Thrombosis and Haemostasis.

Individuals with cancer are more than four times as likely as those in the general population to develop venous thromboembolism.

Apixaban appeared more effective than rivaroxaban in preventing recurrent venous thromboembolism without major bleeding events, according to results of a retrospective study published in The Lancet Haematology.

Patients with thrombophilia had low rates of venous thromboembolism recurrence and bleeding events after treatment with direct oral anticoagulants, according to results of a meta-analysis published in Journal of Thrombosis and Haemostasis.