Hematology News

ORLANDO — Researchers identified proteins that began to change within 8 days of initiating siltuximab in patients with idiopathic multicentric Castleman disease, a rare immune system disorder, according to a video interview at ASH Annual Meeting & Exposition.

ORLANDO — SB-525 gene therapy resulted in dose-dependent and sustained increases in Factor VIII levels in adult patients with severe hemophilia A, according to follow-up data from the Alta study presented at ASH Annual Meeting and Exposition.

ORLANDO — In this video at the ASH Annual Meeting and Exposition, Sriram M. Krishnaswamy, PhD, of the University of Pennsylvania and Children’s Hospital of Philadelphia, discusses efforts to better understand molecular mechanisms, biochemistry and structural biology of blood coagulation.

Treatment with Doptelet was cost-effective for the treatment of thrombocytopenia in patients with chronic liver diseases compared with other treatment options, according to data presented at the American Society of Hematology meeting.

Study findings published in JAMA showed no benefit in using fresh red blood cells — cells stored for a maximum of 7 days — over older red blood cells in critically ill pediatric patients receiving transfusion.

ORLANDO, Fla. — In this video at the ASH Annual Meeting and Exposition, Steven W. Pipe, MD, professor of pediatrics and pathology at the University of Michigan, reviews recent innovations in hemophilia and incorporating gene therapy into practice.

ORLANDO – Despite clinical evidence that hemophilia B presents with less severity on a clinical level than hemophilia A, patients report similar quality of life and those with B have more obesity, according to a presentation at ASH Annual Meeting and Exposition.

ORLANDO — Sutimlimab, a first-in-class selective inhibitor of the complement pathway, induced rapid improvement in hemoglobin levels and reduced the need for transfusions among patients with cold agglutinin disease, according to results of the phase 3 CARDINAL study.

ORLANDO — Giving birth via cesarean section appeared to be associated with twice the risk for postpartum hemorrhage among women with mild factor XI deficiency compared with controls, according to results of a retrospective study presented at ASH Annual Meeting and Exposition.

ORLANDO — ASH named three Choosing Wisely Champions today at its Annual Meeting and Exposition, recognizing clinicians who have implemented projects to improve quality and reduce costs at their institutions.