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Genitourinary Cancer News
Adjuvant nivolumab extends DFS in urothelial carcinoma subset
Adjuvant nivolumab significantly prolonged DFS compared with placebo for patients with high-risk, muscle-invasive urothelial carcinoma, according to topline data released by the agent’s manufacturer.
First-line nivolumab-cabozantinib superior to sunitinib for advanced renal cell carcinoma
Nivolumab plus cabozantinib conferred superior PFS, OS and response rates compared with sunitinib as a first-line treatment for advanced renal cell carcinoma, according to results of a phase 3 study presented at ESMO Virtual Congress 2020.
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Radiotherapy for certain childhood cancers linked to long-term cardiometabolic effects
Adults who received radiation therapy during childhood for abdominal and pelvic cancers appeared more likely than the general population to experience body composition abnormalities and worse cardiometabolic outcomes, study results showed.
FDA grants priority review to fixed-dose Imfinzi for lung, bladder cancer
The FDA granted priority review to durvalumab for administration in a 4-week, fixed dose regimen for the treatment of patients with non-small cell lung cancer and bladder cancer, according to a manufacturer-issued press release.
Cytoreductive nephrectomy may benefit certain patients with renal cell carcinoma
Cytoreductive nephrectomy may extend OS for a well-selected population of patients with metastatic renal cell carcinoma, according to study results published in Cancer.
Black children less likely to receive proton therapy than white children
Black children with solid cancers appeared less likely to receive proton radiotherapy than their white counterparts, according to an analysis of Children’s Oncology Group trial data published in a research letter in JAMA Oncology.
FDA grants breakthrough therapy designation to MK-6482 for renal cell carcinoma subtype
The FDA granted breakthrough therapy designation to MK-6482 for the treatment of certain patients with von Hippel-Lindau disease-associated renal cell carcinoma, according to a press release from the agent’s manufacturer.
Screwing up cancer care
These are times when, under assault from the COVID-19 pandemic and many parts of government, those of us who are relatively powerless can seek to regain control by influencing what we can influence.
Percutaneous cryoablation prolongs survival in early-stage renal cell carcinoma
Percutaneous cryoablation appeared safe and improved 10-year survival outcomes compared with partial or radical nephrectomy among patients with early-stage renal cell carcinoma, according to study results published in Radiology.
Atezolizumab plus chemotherapy improves PFS in metastatic urothelial carcinoma
Atezolizumab plus platinum-based chemotherapy prolonged PFS as first-line therapy for patients with metastatic urothelial carcinoma, according to results of the randomized phase 3 IMvigor130 trial published in The Lancet.