Gastrointestinal Cancer News

Although cancer death rates in the U.S. continue to decline, biennial research from the American Cancer Society shows that nearly half of all cancer deaths involve disease with known modifiable risk factors.

Sedentary TV viewing for prolonged periods of time appeared associated with an increased risk for young-onset colorectal cancer, especially rectal cancer, according to results of a prospective study published in JNCI Cancer Spectrum.

ATLANTA — Patients with advanced BRCA- or PALB2-mutated pancreatic cancer sensitive to platinum-based chemotherapy demonstrated sustained clinical responses to maintenance treatment with rucaparib, according interim data from an ongoing phase 2 trial presented at American Association for Cancer Research Annual Meeting.

ORLANDO — The use of targeted therapies and immunotherapies are evolving oncology clinical practice from a “one-size-fits-all” approach to a personalized approach based on an induvial patient’s biology, according to a presenter at Community Oncology Alliance Annual Conference.

Patients with hepatocellular carcinoma who had a potential live donor at listing for liver transplantation had a significantly lower risk for mortality compared with those who waited for a deceased donor graft, according to recently published data.

ATLANTA — Adults at high risk for HIV infection based on injectable drug use or high-risk sexual behavior showed low rates of HPV vaccination, according to study results presented at American Association of Cancer Research Annual Meeting.

ATLANTA — The experimental oncolytic adenovirus telomelysin, or OBP-301, in combination with radiotherapy, demonstrated feasibility and conferred clinical benefit among patients with esophageal cancer deemed unfit for standard surgery or chemotherapy, according to results from a phase 1 dose-escalation trial presented at American Association for Cancer Research Annual Meeting.

ATLANTA — Excess body weight before age 50 years may increase pancreatic cancer mortality risk to a greater degree than excess weight at older ages, according to results from the Cancer Prevention Study II presented at American Association for Cancer Research Annual Meeting.

ATLANTA — The combination of the experimental CD40 antibody APX005M with nivolumab and standard chemotherapy demonstrated a manageable safety profile and promising antitumor activity among previously untreated patients with , according to results of an open-label, multicenter study presented at American Association for Cancer Research Annual Meeting.

ATLANTA — Patients with rare, high-grade neuroendocrine tumors derived clinical benefit from a combination of the immune checkpoint inhibitors ipilimumab, which targets CTLA-4, and nivolumab, which targets PD-1, according to results from the phase 2 DART trial presented at American Association for Cancer Research Annual Meeting.