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Cell Therapy News
CAR-T recipients report higher rates of ‘potentially serious’ toxicities
Individuals with relapsed or refractory lymphoma who received chimeric antigen receptor T-cell therapy experienced a wide range of adverse events compared with those who received other treatments, study results showed.
FDA grants accelerated approval to immunotherapy for unresectable or metastatic melanoma
The FDA has granted accelerated approval to a tumor-derived autologous T cell immunotherapy indicated for the treatment of adult patients with unresectable or metastatic melanoma.
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Language minimizing adverse events in abstracts ‘harmful,’ can affect patient care
Use of subjective minimizing terminology, such as “safe” and “tolerable,” when discussing treatment-related toxicities occurs frequently at oncology and hematology conferences, according to a study published in Journal of Cancer Policy.
BLOG: ALL relapse prevention with HSCT after CD19 CAR T-cell therapy remission
Allogeneic hematopoietic stem cell transplantation after CD19 chimeric antigen receptor T-cell therapy is thought to improve leukemia-free survival.
CAR-T delivers ‘amazing’ drug-free remission in autoimmune diseases
Chimeric antigen receptor T-cell therapy produced persistent, drug-free remission in patients with one of three different B-cell autoimmune diseases, researchers reported at ASH Annual Meeting and Exhibition.
FDA requires boxed safety warning for all CAR T-cell therapies
The FDA has requested manufacturers of commercially available chimeric antigen receptor T-cell therapies now include a boxed safety warning regarding the risk for secondary T-cell malignancies on prescribing labels.
Early-phase CAR-T for multiple myeloma shows ‘amazing’ safety, ‘encouraging’ efficacy
Results of a phase 1 trial for chimeric antigen receptor T cells targeting an orphan receptor in patients with relapsed or refractory multiple myeloma “thrilled” researchers, based on data presented at ASH Annual Meeting and Exhibition.
As CAR-T emerges, stem cell transplants for lymphoma in ‘marked decline’
SAN DIEGO — The volume of hematopoietic stem cell transplantation procedures for advanced diffuse large B-cell lymphoma has declined precipitously since 2019, study results presented at ASH Annual Meeting and Exhibition showed.
FDA official says CAR-T ‘incredibly beneficial’ despite secondary malignancy risk
Benefits of chimeric antigen receptor T-cell therapy far outweigh the risks involved, including secondary T-cell malignancies, according to Peter Marks, MD, PhD, director of the FDA’s Center for Biologic Evaluation and Research.
Liso-cel CAR-T cost-effective as second-line treatment for advanced lymphoma
Researchers found lisocabtagene maraleucel to be a cost-effective second-line treatment option for patients with relapsed or refractory diffuse large B-cell lymphoma, study findings published in Blood Advances showed.
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Headline News
WikiGuidelines group publishes first new UTI guidance in 14 years
November 11, 20243 min read -
Headline News
Q&A: Industrial fires present unique respiratory health risks
November 11, 20244 min read -
Headline News
Physicians encouraged to conduct oral food challenges for infants, toddlers
November 12, 20247 min read
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Headline News
WikiGuidelines group publishes first new UTI guidance in 14 years
November 11, 20243 min read -
Headline News
Q&A: Industrial fires present unique respiratory health risks
November 11, 20244 min read -
Headline News
Physicians encouraged to conduct oral food challenges for infants, toddlers
November 12, 20247 min read