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Cell Therapy News
Biomarker predicts poor response to CAR-T, points way to personalized, gene-edited therapy
Researchers have identified CD58 status as a predictive marker for durable responses to CD19-directed chimeric antigen receptor T-cell therapy in patients with large B-cell lymphoma.
Novel T-cell therapy shows promise to treat COVID-19 in high-risk patients
An off-the-shelf, virus-specific T-cell therapy demonstrated proof of concept to enter a clinical trial for the treatment of severe COVID-19 infection, according to study results presented at the virtual ASH Annual Meeting and Exposition.
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CAR-T confers durable clinical benefit in high-risk indolent non-Hodgkin lymphoma
More than 90% of patients with advanced-stage indolent non-Hodgkin lymphoma had an objective response to treatment with axicabtagene ciloleucel, according to data presented at the virtual ASH Annual Meeting and Exposition.
Cancer researchers receive NIH Director’s New Innovator Award
Several oncology researchers received the NIH Director’s New Innovator Award.
SITC creates endowed scholars fund, announces inaugural recipient
The Society for Immunotherapy of Cancer created the Steven A. Rosenberg, MD, PhD, Endowed Scholars Fund.
A decade of success: CAR-T pioneers reflect on past, look toward future
Ten years ago, researchers at NCI reported use of CD19-directed chimeric antigen receptor T-cell therapy that successfully induced remission in a patient with follicular lymphoma.
Pediatric cancer treatment can cause long-term dental, bone, skin, liver, immunity issues
Late effects of pediatric cancer treatment may not be readily apparent to primary care clinicians or specialists who follow childhood cancer survivors over the long term.
Tumor-infiltrating lymphocytes plus pembrolizumab active in metastatic HNSCC
The combination of an investigational cell therapy using tumor-infiltrating lymphocytes and pembrolizumab induced responses among a small cohort of patients with metastatic head and neck squamous cell carcinoma, study results showed.
Tumor-infiltrating lymphocytes plus pembrolizumab active in metastatic HNSCC
The combination of an investigational cell therapy using tumor-infiltrating lymphocytes and pembrolizumab induced responses among a small cohort of patients with metastatic head and neck squamous cell carcinoma, study results showed.
FDA lifts hold on clinical trial for allogeneic CAR-T for advanced myeloma
The FDA lifted its clinical hold on a study evaluating UCARTCS1 for the treatment of patients with relapsed or refractory multiple myeloma, according to a press release from the agent’s manufacturer.