Bone Marrow Transplantation News

SALT LAKE CITY — An altered version of the Hopkins conditioning regimen may lead to more stable donor engraftment without severe toxicity among patients with sickle cell disease who undergo haploidentical hematopoietic stem cell transplantation, according to study data presented at the BMT Tandem Meetings.

Peripheral blood stem cell grafts appeared associated with increased risk for acute graft-versus-host disease compared with bone marrow among patients undergoing hematopoietic stem cell transplantation for acute myeloid leukemia and acute lymphoblastic leukemia, according to a study published in Cancer.

SALT LAKE CITY — Treatment with the novel drug KD025 appeared well tolerated and showed encouraging clinical responses for patients with steroid-dependent chronic graft-versus-host disease, according to results of a phase 2a open-label trial presented at the BMT Tandem Meetings.

SALT LAKE CITY — Chimeric antigen receptor T-cell therapy may have a synergistic role with hematopoietic stem cell transplantation to improve leukemia-free survival without an increased risk for severe graft-versus-host disease among patients with acute lymphoblastic leukemia, according to study results presented at the BMT Tandem Meetings.

SALT LAKE CITY — Use of herpes zoster vaccine following an autologous hematopoietic stem cell transplant showed a vaccine efficacy of 68% with a clinically acceptable safety profile, according to study results presented at the BMT Tandem Meetings.

SALT LAKE CITY — Hematopoietic stem cell transplant survivors who received umbilical cord blood grafts appeared less likely to experience bone loss and cardiac complications than survivors who received HLA-matched unrelated donor grafts, according to results of a single-center analysis presented at the BMT Tandem Meetings.

SALT LAKE CITY — Among patients with severe hemoglobinopathies, greater total body irradiation followed by nonmyeloablative haploidentical allogeneic bone marrow transplant and posttransplant cyclophosphamide appeared associated with decreased graft failure, according to study results presented at the BMT Tandem Meetings.

SALT LAKE CITY — Adults treated with mycophenolate mofetil and tacrolimus plus cyclophosphamide after allogeneic hematopoietic stem cell transplantation using reduced-intensity conditioning had superior graft-versus-host disease-related outcomes compared with other novel approaches, according to late-breaking study results presented at the BMT Tandem Meetings.

SALT LAKE CITY — Consuming human milk modified the intestinal microbiome and appeared associated with reduced inflammation and graft-versus-host disease among children aged younger than 5 years who underwent hematopoietic stem cell transplantation, according to results presented at the BMT Tandem Meetings.

SALT LAKE CITY — A diverse gut microbiota demonstrated a local protective effect among patients with nongastrointestinal or upper gastrointestinal acute graft-versus-host disease, according to study results presented at the BMT Tandem Meetings.