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Bone Marrow Transplantation News
High-dose irradiation before HSCT increases risk for subsequent malignancies
Survivors of allogeneic hematopoietic cell transplantation who underwent high-dose total body irradiation incurred nearly eight times the risk for subsequent malignant neoplasms compared with the general population, according to study results published in Blood.
African Americans in VA system demonstrate better multiple myeloma outcomes than Caucasians
African American patients with multiple myeloma demonstrated superior OS compared with Caucasian patients in a VA setting with equal treatment access, according to a study published in Blood.
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Higher radiation dose safely reduces graft failure after haploidentical bone marrow transplantation
Increasing the dose of total body irradiation to 400 cGy from 200 cGy greatly reduced graft failure among patients with sickle cell disease or beta-thalassemia who received a haploidentical bone marrow transplant with post-transplantation cyclophosphamide, according to results of a phase 2 prospective study published in The Lancet Haematology.
‘Tremendous racial and ethnic disparity’ observed in access to matched donor stem cells
Patients with cancer who need a bone marrow transplant are less likely to find a suitable match if they are of southern-European or non-European descent, according to results of a prospective study published in Blood Advances.
‘We have to cure’ cancer, says CAR T pioneer Carl H. June, MD
Carl H. June , MD, is about to receive an award for his life’s work — it's not his first and it certainly won’t be his last. Yet, he remains humble about the accolades.
Lentiviral gene therapy with busulfan conditioning safe, effective in infants with SCID-X1
Infants with newly diagnosed X-linked severe combined immunodeficiency, or SCID-X1, demonstrated multilineage engraftment of transduced cells after receiving lentiviral vector gene therapy and nonmyeloablative targeted busulfan conditioning, according to study findings published in The New England Journal of Medicine.
Fungal infections uncommon among ibrutinib-treated patients despite low rate of prophylaxis
FORT WORTH, Texas — Ibrutinib treatment did not appear associated with increased incidence of fungal infections despite a low rate of antifungal prophylaxis among these patients, according to study results presented at HOPA Ahead 2019.
ASH president: Society is ‘extremely committed’ to continuing advocacy for NIH funding
Roy L. Silverstein, MD, began his 1-year term as ASH president in January.
Survival rates after HSCT have not improved among infants with malignant diseases
Infants with malignant diseases who underwent allogeneic hematopoietic stem cell transplantation did not demonstrate improved survival rates over a 15-year period, according to results of a study in JAMA Pediatrics.
Allogeneic transplant fails to confer survival benefit for pediatric leukemia subtype
Allogeneic hematopoietic stem cell transplantation did not significantly improve survival compared with chemotherapy alone among children with newly diagnosed hypodiploid acute lymphoblastic leukemia, according to results of a retrospective study published in Journal of Clinical Oncology.
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