Bone Marrow Transplantation News

ORLANDO — Cytogenic and molecular factors can help predict prognosis of patients with acute myeloid leukemia or myelodysplastic syndrome who relapse after allogeneic hematopoietic stem cell transplantation, according to retrospective study results presented at TCT | Transplantation & Cellular Therapy Meetings.

ORLANDO — Off-the-shelf chimeric antigen receptor T-cell therapy induced durable remissions among patients with relapsed or refractory B-cell malignancies, according to study results presented at TCT | Transplantation & Cellular Therapy Meetings.

ORLANDO — Acute graft-versus-host disease tended to be less severe among patients who underwent haploidentical transplantation with post-cyclophosphamide prophylaxis than those who underwent 8/8 HLA-matched unrelated donor stem cell transplant with standard prophylaxis, according to study results presented at TCT | Transplantation & Cellular Therapy Meetings.

ORLANDO — The anti-diabetic medication sitagliptin significantly reduced incidence of acute graft-versus-host disease after myeloablative allogeneic peripheral blood stem cell transplantation, according to results of a prospective phase 2 study presented at TCT | Transplantation & Cellular Therapy Meetings.

ORLANDO — Autologous and allogeneic hematopoietic stem cell transplantation both conferred encouraging survival outcomes among patients with Waldenström macroglobulinemia, according to results of a systematic review and meta-analysis presented at TCT | Transplantation & Cellular Therapy Meetings.

ORLANDO — Patients with acute myeloid leukemia who failed to achieve complete remission with hypomethylating agent-based therapy still had favorable survival outcomes after hematopoietic stem cell transplantation, according to study results presented at TCT | Transplantation & Cellular Therapy Meetings.

ORLANDO — Myeloablative conditioning before hematopoietic stem cell transplantation conferred a long-term survival advantage compared with reduced-intensity conditioning among patients with acute myeloid leukemia or myelodysplastic syndrome, according to extended follow-up of the randomized phase 3 MAvRIC trial presented at TCT | Transplantation & Cellular Therapy Meetings.

ORLANDO — CPX-351 extended OS compared with 7 + 3 chemotherapy among patients with acute myeloid leukemia and myelodysplasia-related changes who achieved complete remission or complete remission with incomplete neutrophil or platelet recovery, according to an exploratory subgroup analysis of a phase 3 study presented at TCT | Transplantation & Cellular Therapy Meetings.

ORLANDO — Hematopoietic stem cell transplantation after treatment with quizartinib or salvage chemotherapy extended survival among patients with FLT-internal tandem duplication-mutated relapsed or refractory acute myeloid leukemia, according to post-hoc analyses of the randomized QuANTUM-R study presented at TCT | Transplantation & Cellular Therapy Meetings.

ORLANDO — Time to relapse appeared prognostic for survival among individuals with multiple myeloma who underwent CD34 positive-selected allogeneic hematopoietic stem cell transplantation, according to study results presented at TCT | Transplantation & Cellular Therapy Meetings.