Gynecologic Cancer Awareness Month: Regimens extend survival; talc linked to ovarian cancer
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September is Gynecologic Cancer Awareness Month.
The observation has been established to educate the public about prevention, symptoms and risk factors of cervical, ovarian, uterine/endometrial, vaginal and vulvar cancers.
More than 108,000 women will be diagnosed with a form of gynecologic cancer in the United States this year, according to NCI statistics. Approximately 32,000 Americans will die of these malignancies.
In conjunction with Gynecologic Cancer Awareness Month, Healio presents the following updates in research and treatment.
1. The addition of pembrolizumab (Keytruda, Merck) to adjuvant chemotherapy improved DFS for certain women with newly diagnosed high-risk endometrial cancer. Read more.
2. The combination of pembrolizumab and chemoradiotherapy significantly improved OS for women with high-risk locally advanced cervical cancer. Read more.
3. The FDA expanded the approval of dostarlimab-gxly (Jemperli, GSK) for treatment of endometrial cancer. The expanded indication authorizes the regimen for all women with primary advanced or recurrent endometrial cancer. Read more.
4. The addition of the investigational immunotherapy IMNN-001 (Imunon Inc.) to chemotherapy prolonged survival for women with advanced ovarian cancer. Read more.
5. Tisotumab vedotin (Tivdak; Seagen, Genmab) monotherapy improved outcomes for women with recurrent cervical cancer compared with chemotherapy. Read more.
6. Black women have higher rates of early death from tubo-ovarian, cervical and uterine cancers compared with women of other races and ethnicities, according to study findings. Read more.
7. Endometriosis increased risk for ovarian and endometrial cancers. Read more.
8. A trial investigating mirvetuximab soravtansine (Elahere, ImmunoGen) monotherapy for certain patients with platinum-sensitive ovarian cancer met its primary endpoint of improved objective response rate. Read more.
9. Genital talc powder use increased risk for ovarian cancer in cohort of women. Frequent douching and douching during young adulthood also had associations with increased ovarian cancer risk. Read more.
Reference:
- AACR. September is Gynecologic Cancer Awareness Month. Available at: https://www.aacr.org/patients-caregivers/awareness-months/gynecologic-cancer-awareness-month. Accessed Sept. 25, 2024.
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