VIDEO: Biggest challenges in follicular lymphoma

Editor’s note: This is a previously posted video, and the below is an automatically generated transcript to be used for informational purposes. Please notify editor@healio.com if there are concerns regarding accuracy of the transcription.

Follicular lymphoma is a disease that people can have for decades. And so the greatest risk is overdoing the therapy. First, do no harm. We don't wanna administer treatments that are worse than having follicular lymphoma. Like if somebody dies from an infection that happens after giving them cytotoxic chemo, or they have complications from stem cell transplant or CAR-T. Those are the things that keep us up at night is wanting to help, but not wanting to overdo it and cause toxicities that can have like permanent serious effects that continues to be a challenge. The reason it's a challenge for follicular lymphoma is that people can live with the disease for a long time. When you're dealing with acute lymphoblastic leukemia or aggressive diffuse large B-cell lymphoma or aggressive mantle cell then because the disease is so aggressive, you feel justified in offering very high intensity therapies, CAR-T, allergenic transplant, autotransplant, multiple rounds of cytotoxic chemo. So those things make sense when you're doing very aggressive diseases, but follicular lymphoma can be very indolent and can respond to a lot of different treatments and the treatments can last for years. So if you put somebody at risk by trying to give them CAR-T and then they get a bad outcome, you may have deprived them of time that they would have done fine on other less intense therapies. So that that's the biggest challenge is making the more intense therapy safer so the more people can get them.