June 19, 2023
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VIDEO: Alliance study shows two-drug combination has better results than three in CLL
In this video, Michael Choi, MD, discusses the results of the phase 3 Alliance study, pertaining to chronic lymphocytic leukemia, presented at ASCO Annual Meeting.
Choi, a hematologist/oncologist at UC San Diego Moores Cancer Center, highlighted the study, which examined the impact of adding venetoclax (Venclexta; Genentech, AbbVie) to the standard combination therapy of ibrutinib (Imbruvica; Pharmacyclics, Janssen) and obinutuzumab (Gazyva, Genentech) in older patients with CLL.
“This was one example where we learned that when we balance all factors, safety and efficacy, it turns out that more isn’t always better,” Choi said.
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Sources/Disclosures
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Disclosures:
Choi reports receiving research funding for his institution from AbbVie, AstraZeneca, Beigene, Geron, MEI Pharma, Merck, Oncternal Therapeutics, Pharmacyclics, Protagonist Therapeutics and VelosBio, and noncompensated consulting for AbbVie.
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