Race linked to distant uterine cancer recurrence
Click Here to Manage Email Alerts
Even when accounting for histopathology, presentation stage and other covariates, distant recurrence of uterine cancer was more likely to occur in women who are not white, according to a presenter at the virtual ASCO Annual Meeting.
“Although prior studies have reported the differences in recurrence in Black women compared with white women, no study to date has investigated potential differences in location of recurrence,” Camilla Dagum, MD, of Montefiore Medical Center in Bronx, New York, said during a poster presentation. “Our primary objective with this study was to investigate if nonwhite women were more likely to experience distant uterine cancer recurrence.”
Dagum and colleagues retrospectively examined data from 1,205 patients diagnosed with uterine cancer between 2006 and 2016 at Montefiore Medical Center. For the study, they collected information on each patient’s demographics, location of recurrence and other disease characteristics. Categorization of race was based on a patient’s registration in the medical record.
Of those included in the study, 26.5% were white, 39.2% were Black, 26.5% were Hispanic, 7.6% were Asian and 0.3% were classified as “other.”
Of all patients, 223 women (18.5%) had disease recurrence, with Black women experiencing nearly twice the increased risk of cancer recurrence in all locations compared with women who were not Black (OR = 1.99; 95% CI, 1.37-2.88). Black women were also significantly more likely to experience intraperitoneal, distant and nodal recurrences than white women.
When adjusting for covariates, data showed a significant correlation between nonwhite race and risk for distant recurrence (OR = 3.87; 95% CI 1.42-10.54) and non-endometrioid histology (OR = 5.71; 95% CI, 2-16.3). Dagum and colleagues also observed an association between nonwhite race and adjuvant treatment, including chemotherapy (OR = 3.01; 95% CI, 0.6-15.19), radiation therapy (OR = 7.1; 95% CI, 1.54-32.63) and chemoradiotherapy (OR = 5.86; 95% CI, 1.51-22.76), according to the abstract.
The researchers noted these findings likely indicate that race may contribute to distant recurrence of uterine cancer.
“This suggests that the disparate outcomes experienced by nonwhite patients are likely multifactorial and highlight the need for efforts focused on optimizing treatment and improving outcomes of nonwhite women with uterine cancer,” Dagum said. “More research is needed to investigate possible etiologies of the increased rate of uterine cancer recurrence in nonwhite women.”
Collapse
Dagum C, et al. Abstract 5571. Presented at: ASCO Annual Meeting; June 4-8, 2021 (virtual meeting).
Read more about
Click Here to Manage Email Alerts