VIDEO: Natural killer cells provide ‘interesting approach’ to treatment
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Ryan Cassaday, MD, associate professor of hematology at University of Washington, discussed new platforms for cellular immunotherapy and the Devillier presentation of natural killer cells in a therapeutic setting presented at the ASH Annual Meeting and Exposition.
Studies like Devillier’s, according to Cassaday, are examining treatment approaches that exclude gene manipulation and CAR T-cells by using IL-2 stimulated NK cells.
“There are some putative biological reasons why these cells might be a more desirable, selective product than T-cells,” Cassaday told Healio.
“This is one of just several studies that collect donor-derived IL-2 simulated NK cells from patients who have undergone allogeneic stem cell transplantation, and then use these like a donor lymphocyte infusion. They are IL-2 stimulated NK cells, so it's a little bit more selective,” Cassaday said.
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Devillier,R et al. Abstract 64. Presented at: ASH Annual Meeting and Exposition (virtual meeting); Dec. 5-8, 2020.
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