This article is more than 5 years old. Information may no longer be current.
Smoking affects EGFR mutations in lung adenocarcinoma
Click Here to Manage Email Alerts
Smoking status affects the incidence of epidermal growth factor receptor mutations, as well as the spectrum of these mutations, in patients with lung adenocarcinoma.
“These findings provide a clue for further investigation of EGFR mutagenesis,” Jeng-Sen Tseng, MD, of the division of chest medicine and department of internal medicine at Taichung Veterans General Hospital in Taiwan, and colleagues wrote.
Tseng and colleagues evaluated EGFR mutations in 1,175 patients with lung adenocarcinoma treated at three centers between 2001 and 2013.
The researchers used Sanger direct sequencing to assess the mutations, and they reported an overall 59.6% mutation rate. The mutation rate was significantly higher among females than males (69.1% vs. 49.8%), and significantly higher in smokers than nonsmokers (73.8% vs. 29.8%).
When Tseng and colleagues analyzed the spectrum of EGFR mutations, they found smokers were considerably less likely to express L858R mutations (35.2% vs. 50.2%; P = .005) but more likely to express exon 19 deletions (52.8% vs. 38.8%; P = .008).
Among the subgroup of patients who harbored the L858R mutation, smokers demonstrated a higher rate of complex mutations than nonsmokers (34.2% vs. 8.4%; P < .001). – by Jeff Craven
Disclosure: The researchers report no relevant financial disclosures.
Click Here to Manage Email Alerts