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Surgical treatments may reduce ovarian cancer recurrence
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One-sided oophorectomy and radical extirpation of all visible endometriosis were associated with reduced incidence of epithelial ovarian cancer, according to results of a nested case-control study conducted in Sweden.
“Patients with endometriosis are typically treated with hormones or, in more severe cases, surgery,” Anna Sofia-Melin, MD, of the department of medical epidemiology and biostatistics at Karolinska Institute in Stockholm, said in a press release. “We wanted to expand understanding of ovarian cancer risk in women with endometriosis who had some type of surgery or hormone therapy.”
Anna Sofia-Melin
Women with a first-time discharge diagnosis of endometrial disease between 1969 and 2007 were eligible for the study. The analysis included 220 case patients and 416 controls.
Univariate results showed a significant reduction in ovarian cancer risk associated with two factors: one-sided oophorectomy (crude OR=0.42; 95% CI, 0.28-0.62) and radical extirpation of all visible endometriosis (OR=0.37; 95% CI, 0.25-0.55).
This association persisted through multivariable analysis, with one-sided oophorectomy yielding an adjusted OR of 0.19 (95% CI, 0.08-0.46) and radical extirpation of all visible endometriosis linked to an OR of 0.3 (95% CI, 0.12-0.74).
Hormonal treatments for endometriosis did not lower ovarian cancer risk, the researchers reported.
“For women with endometriosis, the role of hormonal treatment and future ovarian cancer risk remains unclear, and further investigation is warranted,” Melin said.
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