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Simplified GOG risk criteria validated in stage IB cervical cancers
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The Gynecologic Oncology Group criteria for treatment of patients with stage IB cervical cancers after radical hysterectomy were validated among women without high risk factors, according to the findings of a validation study.
In addition, the use of a new simplified criteria were found to be as good as the standard GOG criteria.
Researchers examined data from 332 patients with stage IB cervical cancer who had radical hysterectomy. They identified 225 patients without high-risk factors (lymph node metastasis, parametrial invasion, or positive surgical margins) and classified them into low-risk and high-risk groups. Group classification was based on GOG criteria and a new simplified criteria that is based on a group of intermediate risk factors, including large tumor size, deep stromal invasion and lymphvascular space invasion.
Hee-Sug Ryu, MD, PhD, of the department of obstetrics and gynecology at Ajou University Hospital, Suwon, Korea, presented the findings at The Society for Gynecologic Oncologists’ 2010 Annual Meeting on Women’s Cancer in San Francisco.
Based on GOG criteria, researchers identified 140 low-risk patients and 85 high-risk patients. DFS (P=.001) and OS (P=.013) were better among low-risk patients vs. high-risk patients.
Next, the researchers examined outcomes using the new simplified criteria. In this grouping, there were 145 low-risk patients and 80 high-risk patients. Again, low-risk patients had better DFS (P=.001) and OS (P=.013) than high-risk patients.
“The Gynecologic Oncology Group criteria were still valid in a different cohort of patients; new simplified criteria were convenient to apply in practice, and the performance of the new criteria was as good as the Gynecologic Oncology Group’s criteria,” Ryu said.
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