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Salvage transplant safe, feasible for multiple myeloma
Shah N. Cancer. 2011;doi:10.1002/cncr.26662.
Salvage autologous hematopoietic cell transplant should be considered for patients with multiple myeloma who have relapsed after initial transplant, according to the results of a restrospective analysis.
The study included data from 44 patients with multiple myeloma who had undergone a second salvage autologous hematopoietic cell transplant between 1992 to 2008.
The patients had a median age of 55 years at the time of second transplant and had a median time of 30 months between first and second transplant.
Overall, the second transplant was well tolerated with acceptable toxicity. Twenty-three percent of patients had a grade-3 or higher nonhematologic toxicity. The median time to neutrophil engraftment after salvage transplant was 10 days and the median time to platelet engraftment was 11 days.
When examining survival outcomes, data indicated that 11% of patients achieved a complete response or very good partial response. In addition, two patients had stable disease and one had progressive disease.
After salvage transplant, the median PFS was 12.3 months and the median OS was 31.7 months.
Overall, 18% of patients had an improvement in their multiple myeloma due to the salvage transplant.
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