Motility News

Phase 2 proof-of-concept data presented at the Endocrine Society Annual Meeting indicated efficacy of relamorelin, a ghrelin agonist from Motus, for anorexia nervosa.

Enrollment concluded in a phase 2b clinical trial of relamorelin for the treatment of gastroparesis in patients with type 1 and type 2 diabetes, the manufacturer announced.

Shionogi has submitted New Drug Applications for a once-daily, oral 0.2 mg tablet of naldemedine for the treatment of opioid-induced constipation in the U.S. and Japan, according to a company press release.

Cairn Diagnostics has launched the 13-C-Spirulina Gastric Emptying Breath Test for the diagnosis of gastroparesis, according to a press release.

For patients who underwent antireflux surgery, those who had vagus nerve injury also had significantly less effective reflux control and higher re-operation rates in the long-term, according to the results of a recent study.

Transoral incisionless fundoplication provides durable control of chronic GERD symptoms, according to 3-year follow-up data from the TEMPO trial presented at the Society of American Gastrointestinal and Endoscopic Surgeons 2016 Annual Meeting.

In patients with functional dyspepsia and weight loss, the antidepressant and H1-, alpha-2-, 5-hydroxytryptamine-2c- and 5-hydroxytryptamine-3-receptor antagonist mirtazapine was found to significantly improve early satiation, quality of life, gastrointestinal-specific anxiety, nutrient tolerance and weight loss, according to results from a randomized, double-blind, placebo-controlled mechanistic pilot trial.

The FDA’s Gastroenterology and Urology Devices Panel unanimously voted that the Topas System for the treatment of women with fecal incontinence has reasonable assurance of safety and efficacy.

Naldemedine, an oral, peripherally acting mu-opioid receptor antagonist in development for the treatment of opioid-induced constipation, showed significant benefit vs. placebo in a phase 3 study of patients with chronic noncancer pain, according to a press release.

Engaging in anal intercourse was found to be associated with an increased risk for fecal incontinence, especially among men who have sex with men, according to an analysis of national survey data.