Malabsorption News

Patients with celiac disease aged younger than 65 years who were vaccinated against streptococcal pneumonia had a lower risk for community-acquired pneumonia, but only a minority of celiac patients were vaccinated, according to a recent study.

Compared with other ethnic groups in the United States, individuals from the Punjab region of India were found to have the highest prevalence of celiac disease in a cross-sectional study of patients who underwent duodenal biopsy.

A study of the clinical implications and presentation of ultra-short celiac disease, in which villous atrophy is confined to the duodenal bulb, found that the diagnosis may represent early stage or limited celiac disease with a milder clinical phenotype and infrequency of nutritional deficiencies. Moreover, the study found that a single biopsy of the duodenal bulb significantly increases the diagnostic yield for celiac disease.

Microbiome analysis of duodenal biopsies from adults with active celiac disease revealed significant dysbiosis and an increased abundance of a “peculiar” bacterial strain called Neisseria flavescens.

Researchers have identified a previously unrecognized long noncoding RNA, lnc13, that may play a role in the intestinal inflammation associated with celiac disease, according to new research published in Science.

Celimmune has begun screening patients for its phase 2 clinical study of AMG 714, an anti-interleukin-15 monoclonal antibody in development for the treatment of refractory celiac disease Type II, also known as refractory sprue, according to a company press release.

Celiac disease and non-celiac gluten sensitivity may share common pathophysiological mechanisms, as patients with these conditions showed similar neurological manifestations that responded equally to a gluten-free diet, according to recent study data.

The European Society for Pediatric Gastroenterology, Hepatology and Nutrition has released a position paper stating that new evidence shows age of gluten introduction has no effect on the risk for developing celiac disease in at-risk infants.

Rosacea had a significant association with type 1 diabetes mellitus, celiac disease, multiple sclerosis and rheumatoid arthritis, according to recently published study results.

Results from a meta-analysis showed that the pooled prevalence of celiac disease among first-degree relatives of celiac patients was 7.5%, and significantly varied based on relationship, gender and geographic location.