Liver/Biliary Disorders News

Vibration-controlled transient elastography and serum-based noninvasive tests show a significant discrepancy in detecting liver fibrosis, according to study findings published in Obesity.

Chronic hepatitis B virus infection was positively linked with severe hepatic necroinflammation in children with metabolic dysfunction-associated steatotic liver disease but did not appear to affect hepatic fibrosis, according to data.

Topline data from the phase 2b FASCINATE-2 trial showed “statistically significant improvement” for denifanstat in biopsy-confirmed nonalcoholic steatohepatitis with stage 2 or stage 3 fibrosis at 52 weeks, Sagimet Biosciences announced.

Screening for liver fibrosis was associated with improved self-reported alcohol consumption, diet, exercise and weight after 6 months among patients at risk for liver disease, with lifestyle changes persisting through 2 years.

Sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists were associated with lower risk for cardiovascular events in type 2 diabetes, with or without metabolic dysfunction-associated steatotic liver disease.

Offspring born to mothers with prenatal or third trimester intestinal infection or genitourinary tract infection experienced a significantly higher risk for biliary atresia, according to a study in JAMA Network Open.

Patients diagnosed with cryptogenic pyogenic liver abscess had a “significantly higher incidence” of colorectal cancer up to 3 years from diagnosis compared with matched controls, highlighting the importance of CRC screening, data showed.

Use of nonselective beta-blockers was associated with stage 2 acute kidney injury and all-cause mortality among patients with decompensated cirrhosis waitlisted for liver transplantation, data showed.

Each January, Alcohol Change UK runs Dry January, a post-holiday campaign that encourages people to abstain from alcohol for 31 days at the beginning of the year and drink more healthily year-round.

Older adult patients with acute-on-chronic liver failure had significantly higher waitlist mortality but “acceptable” 1-year survival after liver transplantation, according to data in Clinical Gastroenterology and Hepatology.