Liver/Biliary Disorders News

Arrowhead Pharmaceuticals announced that the first patient has been treated in Takeda Pharmaceuticals’ phase 3 clinical trial of fazirsiran for the treatment of alpha-1 antitrypsin deficiency associated liver disease.

A 2022 outbreak of unexplained acute severe hepatitis in children has been linked to a strain of adeno-associated virus 2, supporting the theory that disease pathogenesis results from viral coinfection, according to data reported in Nature.

Compared with daily calorie restriction, time-restricted eating did not achieve additional benefits for reducing intrahepatic triglyceride content or body fat among patients with nonalcoholic fatty liver disease and obesity.

Although semaglutide did not “significantly improve” fibrosis in patients with nonalcoholic steatohepatitis and compensated cirrhosis, notable improvements were reported in cardiometabolic parameters and markers of liver fat and injury.

Patients in U.S. counties with higher poverty were less likely to undergo liver metastasectomy for colorectal liver metastasis, suggesting that access to surgery for complex gastrointestinal cancers may be affected by social determinants.

A 2011 FDA mandate, which limited acetaminophen dosage to 325 mg/tablet in prescription acetaminophen and opioid products, correlated with a decrease in yearly hospitalizations and cases of acute liver failure related to toxicity.

Lean patients with nonalcoholic fatty liver disease had significantly higher mortality than non-lean patients, despite having lower rates of cirrhosis and diabetes, according to research in Alimentary Pharmacology & Therapeutics.

Every year nearly 3 million patients are diagnosed with hepatitis B and C infections, ultimately leading to 1.1 million deaths worldwide, WHO reported.

In 2015, WHO initiated a campaign to eliminate hepatitis B and C worldwide.

Being prescribed a 90-day or a “mixed duration” supply of entecavir or tenofovir disoproxil fumarate was associated with higher fill rates among commercially insured patients with chronic hepatitis B, researchers found.