Irritable Bowel Syndrome News

Emerging therapies in Crohn’s disease, specifically mongersen and Stelara, as well as the low FODMAPs diet in irritable bowel syndrome were among the most popular news topics covered by Healio Gastroenterology this year.

Plecanatide improved abdominal pain and constipation in patients with constipation-predominant irritable bowel syndrome in the second of two phase 3 clinical trials, the manufacturer announced.

Two colonic release formulations of linaclotide showed improved abdominal pain relief in patients with irritable bowel syndrome, while one of them also showed improvement in bowel habits in a phase 2b trial, Ironwood and Allergan announced.

Different psychotherapies showed comparable improvements in the mental health of patients with irritable bowel syndrome, but cognitive behavior therapy showed the greatest improvements in daily functioning, according to a recently published review and meta-analysis.

Because complex interactions between the brain, the gut and the environment contribute to functional gastrointestinal disorders, effective treatments should address both biological and psychological factors, experts say.

Psychological interventions are increasingly recognized as effective for treating patients with functional gastrointestinal disorders like irritable bowel syndrome, functional constipation, functional dyspepsia and others. However, a variety of factors present challenges to delivering these treatments to patients.

Plecanatide improved abdominal pain and constipation in patients with constipation-predominant irritable bowel syndrome in the first of two phase 3 clinical trials, the manufacturer announced.

ORLANDO — Patients with inflammatory bowel disease who also have irritable bowel syndrome, especially women, may have an increased risk for chronic fatigue, according to a poster presented at AIBD 2016.

Bifidobacterium infantis 35624, a probiotic often used to treat patients with irritable bowel syndrome, was not superior to placebo for improving abdominal discomfort and bloating in a healthy non-patient population studied in a double blind randomized controlled trial.

Exposure-based cognitive behavior therapy delivered via the internet improved gastrointestinal symptoms and quality of life in adolescents with irritable bowel syndrome, according to randomized controlled trial results.