Intestinal Disorders News

Individuals who experience sensitivity to wheat in the absence of celiac disease or wheat allergy had compromised intestinal epithelial barrier integrity and resulting systemic immune activation, according to the results of a new study published in Gut.

The FDA has given Investigational Device Exemption approval to LifeBond for a clinical trial of its LifeSeal surgical sealant kit, designed to provide an elastic staple-line reinforcement to reduce leakage in GI resection procedures, according to a press release from the manufacturer.

Early life antibiotic exposure, delivery by cesarean section and formula feeding were associated with a disrupted development of the gut microbiome and reduced microbial diversity in infants, according to study results published in Science Translational Medicine.

Although a third of patients with microscopic colitis experienced symptoms that overlap with irritable bowel syndrome, researchers did not observe increased prevalence of microscopic colitis among irritable bowel syndrome patients vs. other patients with diarrhea undergoing colonoscopy, according to the results of a meta-analysis.

LifeSeal Surgical Sealant has received CE marking for use in the European Union as an adjunct to a suture or staple-line to minimize leakage during GI resection procedures, the company announced. The product has also received an Expedited Access Pathway designation and priority processing status from the FDA.

Target enrollment has been reached for the CPP FAP-310 trial, a phase 3 clinical trial evaluating CPP-1X/sulindac combination therapy in adults with familial adenomatous polyposis, according to a press release from the drug maker.

Black patients with five common gastrointestinal diagnoses had fewer major complications and lower mortality rates when they received treatment at hospitals with greater inpatient racial diversity, according to data published in American Journal of Gastroenterology.

Combination therapy with sulindac and erlotinib reduced duodenal polyp burden in patients with familial adenomatous polyposis, according to the results of a double blind, randomized, placebo-controlled trial.

New data published in Cell from Cleveland Clinic researchers suggest that gut-derived metabolite trimethylamine N-oxide triggers over-reactive platelet function, increasing the risk for thrombosis, MI and stroke.

The ACG has released a new clinical guideline on the management of patients with acute lower gastrointestinal bleeding, which provides a number of recommendations regarding initial evaluation and management, the role of colonoscopic and non-colonoscopic diagnostic and therapeutic strategies, and prevention of recurrent bleeding events.