Infection News

Sustained virologic response after treatment for hepatitis C correlated with a reduced risk for several extrahepatic manifestations including type 2 diabetes, chronic kidney disease, and mood and anxiety disorders.

Finch Therapeutics has raised $53 million in Series C financing to support the clinical development of its microbial therapies, including CP101, an oral microbiome capsule for recurrent Clostridioides difficile infection.

In a follow-up analysis of participants in clinical trials, researchers found that patient-reported outcome scores increased in patients who achieved sustained virologic response after treatment for hepatitis C, whereas scores decreased in those who did not.

Liver disease in children and adolescents takes on as many forms as in adults, including viral hepatitis, autoimmune diseases, fatty liver disease, and even the pediatric-specific biliary atresia that occurs in infants.

Passively chlorinating water sources using solid tablet chlorine dosers significantly reduced the rate of childhood diarrhea in two communities in Dhaka, Bangladesh, according to results from a double-blind, cluster-randomized controlled trial published in The Lancet Global Health.

Most patients with hepatitis C in Africa have genotypes outside of the common and easily cured genotype 1a and genotype 1b, which has led to a suboptimal rate of sustained virologic response.

Every additional day of antibiotic administration in the NICU results in lower anaerobe richness and butyrate producers, with more potential pathogens dominating the gut, study findings published in Clinical Infectious Diseases suggest.

The CDC’s Advisory Committee on Immunization Practices cautions against administering the rotavirus vaccine to infants in a NICU or nursery because of the potential for horizontal transmission of the live vaccine-strain virus. It also recommends age restrictions on the timing of the rotavirus vaccine, with the first dose to be given before 15 weeks of age. These intersecting recommendations create a vulnerable population of infants who require a prolonged intensive care stay and might age out of vaccine eligibility, according to a study published in the Journal of the Pediatric Infectious Diseases Society.

Treatment with Vosevi, a combination of sofosbuvir, velpatasvir and voxilaprevir, was an effective and safe therapy for patients with prior direct-acting antiviral treatment failure, according to findings published in the Journal of Hepatology.

Healio Gastroenterology and Liver Disease has compiled a list of some of the top stories we reported in July.