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Hepatitis C News
Shortened duration triple therapy fails in genotype 3 HCV
AMSTERDAM — Six weeks of triple combination therapy induced sustained virologic response in a cohort of patients with genotype 1 HCV but not genotype 3, according to data presented at the International Liver Congress.
VIDEO: Viral decline, drug level measured with fine-needle aspiration
AMSTERDAM — In this exclusive video from International Liver Congress, Andrew Talal, MD, MPH, from the University of Buffalo, New York, discusses results of a study that used fine-needle aspiration to determine HCV RNA decline in plasma in patients treated with a direct-acting antiviral regimen.
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Harvoni shows safety, efficacy in younger pediatric population
AMSTERDAM — A fixed, half-dose combination of Harvoni was associated with sustained virologic response rates of 99% or greater in a cohort of children aged 6 to 11 years, according to data presented at the International Liver Congress.
Generic therapies ‘overtook’ branded DAAs in 2016
AMSTERDAM — A presenter at today’s viral hepatitis session at the International Liver Congress called on the clinical community to push the envelope in using generic direct-acting antiviral therapies.
One-third of UK adolescents with HCV developed serious liver disease
AMSTERDAM — Approximately one-third of children under 18 years in the United Kingdom with hepatitis C developed serious long-term liver disease, according to data presented at the International Liver Congress.
Zepatier yields high SVR12 in real-world VA cohort
AMSTERDAM — Zepatier was associated with SVR12 rates above 95% in a real-world, Veterans Affairs cohort, according to data presented at the International Liver Congress.
Norfloxacin bested placebo in reducing mortality in HCV cirrhosis
AMSTERDAM — Norfloxacin yielded improved 6-month survival compared with placebo in a cohort of HCV patients with Child-Pugh C cirrhosis, according to data presented at the International Liver Congress.
DAAs may impact inflammatory markers in cirrhosis, HCC surveillance
AMSTERDAM — Curing patients with cirrhosis of hepatitis C virus could alter the inflammatory milieu and have an impact on the way CD8+ T-cells surveil potential carcinoma, according to data presented at the International Liver Congress.
WHO launches first ever global hepatitis report
AMSTERDAM — While progress has been made in the global burden of hepatitis, there is still much to be done to achieve eradication by 2030, according to WHO, which released its first ever global hepatitis report at the International Liver Congress.
Eight weeks of glecaprevir/pibrentasvir effective in genotype 3 HCV
AMSTERDAM — Eight weeks of the fixed-dose combination of glecaprevir/pibrentasvir produced a 95% sustained virologic response rate in patients with genotype 3 hepatitis C virus, according to data presented at the International Liver Congress.