Polyethylene glycol, ascorbic acid cleanse highly effective for colonoscopy prep
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CHARLOTTE, N.C. — Bowel cleansing for colonoscopy with a 1 L polyethylene glycol and ascorbic acid preparation proved highly effective and tolerable, according to a real-world study presented at ACG 2022 Annual Scientific Meeting.
Previous clinical trials have demonstrated the preparation’s high efficacy for bowel cleansing, Cátia Arieira, MD, a gastroenterologist at Hospital Senhora da Oliveira in Guimarães, Portugal, and colleagues reported.
To follow up on past research with real-world study data, Arieira and colleagues conducted an observational, multicenter, retrospective study and included 13,169 outpatients, aged 18 years or older (mean age, 57 years; 48.6% men), who underwent colonoscopy at 12 centers in Spain or Portugal from July 2019 to September 2021.
Patients received the 1 L polyethylene glycol and ascorbic acid preparation as either a split morning/evening dose or same-day regimen (67.2%) before undergoing screening, surveillance or diagnostic colonoscopy. A score of at least 6 on the Boston Bowel Preparation Scale indicated adequate cleansing.
Researchers reported 89.3% overall cleansing success (95% CI, 88.7-89.8), with those on the split-dose regimen achieving 94.7% cleansing success vs. 86.7% in the same-day group (P < .0001). The split-dose regimen also resulted in superior right colon cleansing (65.4% vs. 41.4%; P < .0001).
Almost all patients (97.3%) completed colonoscopy. Incidence of adverse events was 2.3%, with nausea (1.2%), vomiting (0.8%) and abdominal pain (0.2%) among the most reported.
“Results from this large study confirm the high cleansing effectiveness and good tolerability of 1L [polyethylene glycol and ascorbic acid] in real-world settings,” Arieira and colleagues said.
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Arieira C, et al. Abstract S589: One-Liter Polyethylene Glycol + Ascorbic Acid Bowel Preparation Delivers High Levels of Adequate and High-Quality Bowel Cleansing for Colonoscopy. Presented at: ACG Annual Scientific Meeting; Oct. 21-26, 2022; Charlotte, N.C. (hybrid meeting).
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