VIDEO: Microbiome Health Index predicts post-antibiotic dysbiosis
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The Microbiome Health Index for post-Antibiotic dysbiosis was a promising biomarker for predicting antibiotic dysbiosis and subsequent microbiome restoration, according to research published in Frontiers of Microbiology.
“It’s very important that we maintain a healthy microbiome, but there are things that can disrupt or perturb a healthy microbiome to a less healthy state, which we term dysbiosis,” Ken Blount, PhD, chief scientific officer at Rebiotix, a Ferring company, and vice president of microbiome research at Ferring Pharmaceuticals, said in a Healio video exclusive. “We know that antibiotics are an important part of health care practice, but recently, we're also recognizing that broad-spectrum antibiotics can have collateral impact by inhibiting some of the good bacteria that make up our gut microbiome.”
Using longitudinal gut microbiome data, Blount and colleagues developed and validated the Microbiome Health Index for post-Antibiotic dysbiosis (MHI-A); the MHI-A algorithm identifies the abundance of microbiome taxonomic classes that changed and correlated with clinical response following treatment for recurrent Clostrioides difficile infections.
“What we've done is collected microbiome data from a very large set of patients from multiple controlled clinical trials, and we've identified an algorithm that gives us this microbiome health index, or MHI-A, that has a high diagnostic accuracy to identify and distinguish post-antibiotic dysbiosis from a healthy composition,” Blount concluded. “We think it could be potentially useful in the field in a lot of ways.”
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