Gallbladder and biliary tract cancer burden remains high
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The incidence and mortality of gallbladder and biliary tract cancer have increased over the last three decades, according to research published in Cancer.
“The global burden of gallbladder and biliary tract cancer [GBTC] has posed a significant public health challenge over the years,” Guangdong Pan, MM, from the department of hepatobiliary surgery at Liuzhou People’s Hospital in China and colleagues wrote. “Therefore, data regarding GBTC burden estimates and trends in different countries and territories will provide information for further research and policy making to help prevent and treat GBTC.”
Source: Ouyang G, et al. Cancer. 2021;doi:10.1002/cncr.33476.
Researchers collected data from 1990 to 2017 on incidence rates, mortality and disability-adjusted life years (DALYs) from the 2017 Global Burden of Disease Study. They then calculated the estimated annual percent changes to assess trends of GBTC during the study period.
In 2017, there were 210,878 new cases, 173,974 deaths and 3,483,046 DALYs because of GBTC. Those numbers represented 75%, 65% and 52% increases from 1990, respectively.
Investigators also observed higher incidence and death rates in regions with higher Socio-Demographic Index. However, these regions also had decreased age-standardized incidence rates (ASIR) and age-standardized death rates (ASDR). Chile had the higher ASIR (10.38 per 100,000 population) and ASDR (10.43 per 100,000 population), while the largest increases were in Georgia (estimated annual percent changes, ASIR = 3.38; ASDR = 3.39).
Pan and colleagues also found nonlinear associations between ASDR, the Socio-Demographic Index and DALYs in the 21 regional and national levels within the Global Burden of Disease Study.
“GBTC remains a major health burden worldwide,” the investigators wrote. “Our findings may be valuable for policymakers to establish cost-effective methods for the early diagnosis, prevention and treatment of GBTC, reducing its modifiable risk factors, and reversing the increasing trend.”
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