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Pediatric IBD prevalence, incidence rose significantly in Manitoba
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Inflammatory bowel disease among children in Manitoba, Canada, increased during a 30-year period, with the prevalence of ulcerative colitis making the biggest jump, according to recent findings.
Moreover, most of the patients with pediatric inflammatory bowel disease (IBD) appear to live in urban areas, reinforcing the importance of environmental factors in the onset of the condition.
Researchers determined the gender- and age-adjusted annual prevalence and incidence of pediatric IBD in children aged younger than 17 years between 1978 and 2007. Estimates were drawn from the pediatric IBD database from the province’s lone pediatric tertiary center. Annual health statistics from Manitoba were analyzed to calculate population estimates, and data were validated via the University of Manitoba IBD Epidemiology Database for pediatric patients between 1989 and 2000.
The researchers found that the gender- and age-adjusted prevalence of pediatric Crohn’s disease (CD) increased six-fold, from 3.1 per 100,000 in 1978 to 18.9 per 100,000 in 2007 (P<.001), while ulcerative colitis (UC) prevalence grew 18-fold, from 0.7 per 100,000 persons in 1978 to 12.7 per 100,000 in 2007 (P<.001).
During the same period, incidence of pediatric CD rose from 1.2 per 100,000 persons to 4.68 per 100,000 (P<.001). UC incidence also escalated at a similar pace, from 0.47 per 100,000 to 1.64 per 100,000 (P<.001). Researchers said urban children had a higher average annual incidence of IBD than rural children (8.69 per 100,000 vs. 4.75 per 100,000; P<.001).
“The majority of patients were residents of urban Manitoba, confirming the important role of environmental factors in the etiopathogenesis of IBD,” the researchers wrote.
Disclosure: Relevant financial disclosures were not provided by researchers.
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