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Heightened risk of gastric cancer found after intestinal metaplasia diagnosis
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SAN DIEGO — Intestinal metaplasia is significantly associated with the development of gastric cancer in a population of Western patients, a speaker said here.
Researchers examined hospital databases and electronic medical records and found 14 of 675 patients (2.1%) in the intestinal metaplasia of the stomach (IMS) group developed gastric cancer, while only 1 of 1,273 patients (0.1%) in the control group developed gastric cancer (P<.0001), Wissam Bleibel, MD, said during the American College of Gastroenterology meeting.
A multivariate analysis found only IMS — and not H. pylori infection, age, sex or race — was associated with an increased risk for gastric cancer (HR=11.23; P<.025), he said. A univariate analysis found H. pylori also was associated (HR=3.4; P<.05).
“Patients who developed (gastric) cancer were older, with a mean age of 63 in comparison to 50; they had more intestinal metaplasia, involving 93% of the patients in comparison to 34%,” Bleibel said. “H. pylori was more prevalent in the patients who developed gastric cancer, involving around 27%, in comparison to 6% in the patients who did not develop gastric cancer.”
Mean interval between diagnosis ofintestinal metaplasia and gastric cancer was 4 years, he said.
Physicians should consider surveillance esophagogastroduodenoscopy at regular intervals following diagnosis of IMS based on how quickly gastric cancer was found to develop after diagnosis, Bleibel said.
Disclosure: The researchers reported no relevant financial disclosures.
For more information:
Bliebel, W. #3: Intestinal Metaplasia of the Stomach is Associated with an Increased Risk of Gastric Cancer in a Western Population. Presented at: the 2013 American College of Gastroenterology Annual Scientific Meeting; Oct. 11-16, San Diego.